APOE4 Promotes Tonic-Clonic Seizures, an Effect Modified by Familial Alzheimer’s Disease Mutations

Seizures are emerging as a common symptom in Alzheimer’s disease (AD) patients, often attributed to high levels of amyloid β (Aβ). However, the extent that AD disease risk factors modulate seizure activity in aging and AD-relevant contexts is unclear. APOE4 is the greatest genetic risk factor for AD...

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Bibliographic Details

Published in:	Frontiers in Cell and Developmental Biology
Main Authors:	Lorissa Lamoureux, Felecia M. Marottoli, Kuei Y. Tseng, Leon M. Tai
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-03-01
Subjects:	Alzheimer’s disease apolipoprotein E seizure amyloid beta sex
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2021.656521/full