Immune Responses in the Central Nervous System Are Anatomically Segregated in a Non-Human Primate Model of Human Immunodeficiency Virus Infection

The human immunodeficiency virus (HIV) accesses the central nervous system (CNS) early during infection, leading to HIV-associated cognitive impairment and establishment of a viral reservoir. Here, we describe a dichotomy in inflammatory responses in different CNS regions in simian immunodeficiency...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Barbara Tavano, Vicky Tsipouri, Gareth A. D. Hardy, Caroline M. Royle, Michael R. Keegan, Dietmar Fuchs, Steven Patterson, Neil Almond, Neil Berry, Claire Ham, Deborah Ferguson, Adriano Boasso
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-03-01
Subjects:	simian immunodeficiency virus central nervous system neuroinflammation neurotoxicity indoleamine (2,3)-dioxygenase
Online Access:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.00361/full