A Mechanistic Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Approach Informed by In Vitro and Clinical Studies for Topical Administration of Adapalene Gels

<b>Background/Objectives:</b> Adapalene is a synthetic retinoid used as a treatment for acne vulgaris. In this study, we attempted to evaluate the dermal pharmacokinetics of adapalene utilizing experimental and in silico tools. <b>Methods:</b> We utilized three over the count...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Namrata S. Matharoo, Harsha T. Garimella, Thu M. Truong, Saiaditya Badeti, Joyce X. Cui, Sesha Rajeswari Talluri, Amitkumar Virani, Babar K. Rao, Bozena Michniak-Kohn
Format:	Article
Language:	English
Published:	MDPI AG 2025-08-01
Subjects:	adapalene retinoids acne vulgaris topical delivery physiologically based pharmacokinetic modeling pharmacokinetic pharmacodynamic modeling
Online Access:	https://www.mdpi.com/1999-4923/17/9/1108