Defective kinase activity of IKKα leads to combined immunodeficiency and disruption of immune tolerance in humans

Abstract IKKα is a multifunctional serine/threonine kinase that controls various biological processes, either dependent on or independent of its kinase activity. However, the importance of the kinase function of IKKα in human physiology remains unknown since no biallelic variants disrupting its kina...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Gökhan Cildir, Umran Aba, Damla Pehlivan, Denis Tvorogov, Nicholas I. Warnock, Canberk Ipsir, Elif Arik, Chung Hoow Kok, Ceren Bozkurt, Sidem Tekeoglu, Gaye Inal, Mahmut Cesur, Ercan Kucukosmanoglu, Ibrahim Karahan, Berna Savas, Deniz Balci, Ayhan Yaman, Nazli Deveci Demirbaş, Ilhan Tezcan, Sule Haskologlu, Figen Dogu, Aydan Ikinciogulları, Ozlem Keskin, Damon J. Tumes, Baran Erman
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-11-01
Online Access:	https://doi.org/10.1038/s41467-024-54345-4