Phosphomevalonate Kinase Controls β‐Catenin Signaling via the Metabolite 5‐Diphosphomevalonate

Abstract β‐catenin signaling is abnormally activated in cancer. Here, this work screens the mevalonate metabolic pathway enzyme PMVK to stabilize β‐catenin signaling using a human genome‐wide library. On the one hand, PMVK‐produced MVA‐5PP competitively binds to CKIα to prevent β‐catenin Ser45 phosp...

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Bibliographic Details

Published in:	Advanced Science
Main Authors:	Zhiqiang Chen, Xinyi Zhou, Xiaojun Zhou, Yi Tang, Mingzhu Lu, Jianhong Zhao, Chenhui Tian, Mingzhi Wu, Yanliang Liu, Edward V. Prochownik, Fubing Wang, Youjun Li
Format:	Article
Language:	English
Published:	Wiley 2023-04-01
Subjects:	β‐catenin casein kinase Iα hepatocellular carcinoma mevalonate 5‐diphosphate phosphomevalonate kinase
Online Access:	https://doi.org/10.1002/advs.202204909