Baculovirus-Free SARS-CoV-2 Virus-like Particle Production in Insect Cells for Rapid Neutralization Assessment

Virus-like particles (VLPs) resemble authentic virus while not containing any genomic information. Here, we present a fast and powerful method for the production of SARS-CoV-2 VLP in insect cells and the application of these VLPs to evaluate the inhibition capacity of monoclonal antibodies and sera...

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Bibliographic Details

Published in:	Viruses
Main Authors:	Marcel Jaron, Michael Lehky, Marta Zarà, Chris Nicole Zaydowicz, Aidin Lak, Rico Ballmann, Philip Alexander Heine, Esther Veronika Wenzel, Kai-Thomas Schneider, Federico Bertoglio, Susanne Kempter, Reinhard Wolfgang Köster, Silvia Stella Barbieri, Joop van den Heuvel, Michael Hust, Stefan Dübel, Maren Schubert
Format:	Article
Language:	English
Published:	MDPI AG 2022-09-01
Subjects:	virus-like particles (VLPs) SARS-CoV-2 insect cells expression vector antibodies cellular assay
Online Access:	https://www.mdpi.com/1999-4915/14/10/2087