Melittin derived peptide-drug conjugate, M-DM1, inhibits tumor progression and induces effector cell infiltration in melanoma by targeting M2 tumor-associated macrophages

BackgroundMelanoma has the highest mortality rate among all the types of skin cancer. In melanoma, M2-like tumor-associated macrophages (TAMs) are associated with the invasiveness of tumor cells and a poor prognosis. Hence, the depletion or reduction of M2-TAMs is a therapeutic strategy for the inhi...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Chanmi Jeong, Jeongdong Kim, Ik-Hwan Han, Soyoung Kim, Ilseob Choi, Hongsung Kim, Jin-Hyun Jeong, Hyunsu Bae
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-04-01
Subjects:	peptide-drug conjugate melittin mertansine tumor associated macrophages melanoma
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1178776/full