Identifying Potent Nonsense-Mediated mRNA Decay Inhibitors with a Novel Screening System

Nonsense-mediated mRNA decay (NMD) is a quality control mechanism that degrades mRNAs carrying a premature termination codon. Its inhibition, alone or in combination with other approaches, could be exploited to develop therapies for genetic diseases caused by a nonsense mutation. This, however, requ...

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Bibliographic Details
Published in:Biomedicines
Main Authors: Julie Carrard, Fiona Ratajczak, Joséphine Elsens, Catherine Leroy, Rebekah Kong, Lucie Geoffroy, Arnaud Comte, Guy Fournet, Benoît Joseph, Xiubin Li, Sylvie Moebs-Sanchez, Fabrice Lejeune
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Subjects:
nonsense mutation
small molecules
therapy
nonsense-mediated mRNA decay
genetic disease
Online Access:https://www.mdpi.com/2227-9059/11/10/2801

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https://www.mdpi.com/2227-9059/11/10/2801

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