Mechanistic Role of the Mdm2/MdmX Lid Domain in Regulating Their Interactions with p53

p53 functions as a critical guardian of the genome, orchestrating tumor suppression pathways and ensuring the integrity of chromosomal stability. Mdm2 and MdmX, homologous proteins, serve as negative feedback regulators of p53. In approximately half of tumor cases, overexpression of Mdm2/MdmX result...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Qiuyin Wei, Chenqi Li, Yibing Tang, Jinping Bai, Wang Li, Jidong Liu, Zhengding Su, Xiyao Cheng
Format:	Article
Language:	English
Published:	MDPI AG 2025-04-01
Subjects:	tumor suppressor protein p53 Mdm2 MdmX Lid
Online Access:	https://www.mdpi.com/2218-273X/15/5/642