Dual roles for a tick protein disulfide isomerase during the life cycle of the Lyme disease agent

ABSTRACT The protein disulfide isomerase (PDI) family is a group of enzymes that have thiol-disulfide oxidoreductase, disulfide isomerase, and redox-dependent chaperone activities. PDIs facilitate diverse infections in mammalian hosts by directly binding to pathogens, immunomodulation, or enabling m...

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Bibliographic Details

Published in:	mBio
Main Authors:	Xiaotian Tang, Yingjun Cui, Ushuu Namarra, Xiuqi Tian, Freddie Rivas-Giorgi, Erol Fikrig
Format:	Article
Language:	English
Published:	American Society for Microbiology 2024-12-01
Subjects:	protein disulfide isomerase Ixodes scapularis Lyme disease Borrelia burgdorferi infection tick
Online Access:	https://journals.asm.org/doi/10.1128/mbio.01754-24