High-throughput characterization of the role of non-B DNA motifs on promoter function

Summary: Alternative DNA conformations, termed non-B DNA structures, can affect transcription, but the underlying mechanisms and their functional impact have not been systematically characterized. Here, we used computational genomic analyses coupled with massively parallel reporter assays (MPRAs) to...

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Bibliographic Details

Published in:	Cell Genomics
Main Authors:	Ilias Georgakopoulos-Soares, Jesus Victorino, Guillermo E. Parada, Vikram Agarwal, Jingjing Zhao, Hei Yuen Wong, Mubarak Ishaq Umar, Orry Elor, Allan Muhwezi, Joon-Yong An, Stephan J. Sanders, Chun Kit Kwok, Fumitaka Inoue, Martin Hemberg, Nadav Ahituv
Format:	Article
Language:	English
Published:	Elsevier 2022-04-01
Subjects:	non-B DNA Z-DNA G-quadruplex MPRA promoter mutations
Online Access:	http://www.sciencedirect.com/science/article/pii/S2666979X22000313