λ-Carrageenan Oligosaccharides of Distinct Anti-Heparanase and Anticoagulant Activities Inhibit MDA-MB-231 Breast Cancer Cell Migration

In tumor development, the degradation of heparan sulfate (HS) by heparanase (HPSE) is associated with cell-surface and extracellular matrix remodeling as well as the release of HS-bound signaling molecules, allowing cancer cell migration, invasion and angiogenesis. Because of their structural simila...

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Bibliographic Details

Published in:	Marine Drugs
Main Authors:	Hugo Groult, Rémi Cousin, Caroline Chot-Plassot, Maheva Maura, Nicolas Bridiau, Jean-Marie Piot, Thierry Maugard, Ingrid Fruitier-Arnaudin
Format:	Article
Language:	English
Published:	MDPI AG 2019-02-01
Subjects:	λ-carrageenan heparanase anticoagulant depolymerisation cell migration
Online Access:	https://www.mdpi.com/1660-3397/17/3/140