CRISPR/Cas9-Mediated Gene Correction in Osteopetrosis Patient-Derived iPSCs

Background: Osteopetrosis represents a rare genetic disease with a wide range of clinical and genetic heterogeneity, which results from osteoclast failure. Although up to 10 genes have been identified to be related with osteopetrosis, the pathogenesis of osteopetrosis remains foggy. Disease-specific...

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Bibliographic Details

Published in:	Frontiers in Bioscience-Landmark
Main Authors:	Dandan Li, Minglin Ou, Wei Zhang, Qi Luo, Wanxia Cai, Chune Mo, Wenken Liang, Guandong Dai, Lianghong Yin, Peng Zhu, Donge Tang, Yong Dai
Format:	Article
Language:	English
Published:	IMR Press 2023-06-01
Subjects:	crispr/cas9 gene correction osteopetrosis ipscs clcn7
Online Access:	https://www.imrpress.com/journal/FBL/28/6/10.31083/j.fbl2806131