Covalent drug – An emerging framework for targeted drug development

Drug discovery involving covalent drugs has a rich history dating back to the 20th century. Despite their longevity, concerns about safety have relegated covalent drug development to the periphery of research focus. The emergence of the groundbreaking concept of Targeted Covalent Inhibition (TCI) ha...

وصف كامل

التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Results in Chemistry
المؤلفون الرئيسيون:	Ritesh P. Bhole, Govinda O. Joshi, Harshad S. Kapare, Rupesh V. Chikhale, Somdatta Chaudhari
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Elsevier 2024-06-01
الموضوعات:	Covalent drugs Targeted covalent inhibition (TCI) Disease-related proteins Two-step inhibition process Toxicity mitigation strategies
الوصول للمادة أونلاين:	http://www.sciencedirect.com/science/article/pii/S2211715624003114