Deleting ACC1 in platelets alters phospholipidome and reduces platelet activation and thrombosis in mice

Abstract: This study uncovers the pivotal role of acetyl-CoA carboxylase 1 (ACC1) in regulating platelet lipid composition, bioenergetics, activation, and thrombus formation, as demonstrated using a targeted glycoprotein Ibα (GPIbα)-Cre+/− mouse model. By comparing platelet-specific ACC1 knockout mi...

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Bibliographic Details

Published in:	Blood Advances
Main Authors:	Marie Octave, Laurence Pirotton, Emma de Cartier d’Yves, Alice Marino, Jérôme Ambroise, Martin Giera, Bruno Guigas, Audrey Ginion, Valentine Robaux, Marijke Kuijpers, Constance Baaten, Johan W. M. Heemskerk, Zoltan Nagy, Yotis Senis, Davide Brusa, Caroline Bouzin, Luc Bertrand, Christophe Beauloye, Sandrine Horman
Format:	Article
Language:	English
Published:	Elsevier 2025-09-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2473952925003830