Functional Loss of Terminal Complement Complex Protects Rabbits from Injury-Induced Osteoarthritis on Structural and Cellular Level

The terminal complement complex (TCC) has been described as a potential driver in the pathogenesis of posttraumatic osteoarthritis (PTOA). However, sublytic TCC deposition might also play a crucial role in bone development and regeneration. Therefore, we elucidated the effects of TCC on joint-relate...

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Bibliographic Details
Published in:Biomolecules
Main Authors: Jana Riegger, Helga Joos, Valentin Möhler, Frank Leucht, Katrin Rading, Christian Kubisch, Anita Ignatius, Markus Huber-Lang, Rolf E. Brenner
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Subjects:
osteoarthritis
terminal complement complex
TCC
ACLT
PTOA
C6
Online Access:https://www.mdpi.com/2218-273X/13/2/216

Internet

https://www.mdpi.com/2218-273X/13/2/216

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