Lactonase-mediated inhibition of quorum sensing largely alters phenotypes, proteome, and antimicrobial activities in Burkholderia thailandensis E264

IntroductionBurkholderia thailandensis is a study model for Burkholderia pseudomallei, a highly virulent pathogen, known to be the causative agent of melioidosis and a potential bioterrorism agent. These two bacteria use an (acyl-homoserine lactone) AHL-mediated quorum sensing (QS) system to regulat...

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Bibliographic Details

Published in:	Frontiers in Cellular and Infection Microbiology
Main Authors:	Mélanie Gonzales, Laure Plener, Jean Armengaud, Nicholas Armstrong, Éric Chabrière, David Daudé
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-06-01
Subjects:	quorum sensing Burkholderia thailandensis quorum quenching lactonase Acyl-homoserine lactone
Online Access:	https://www.frontiersin.org/articles/10.3389/fcimb.2023.1190859/full