Lipid droplet formation induced by icaritin derivative IC2 promotes a combination strategy for cancer therapy

Abstract Background Lipid metabolism is crucial in cancer progression. Lipid droplets (LDs) generated in cancer cells can act as protective mechanisms through alleviating lipotoxicity under stress conditions. We previously developed IC2 from the Chinese medicine icaritin as an inhibitor of stearoyl-...

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Bibliographic Details

Published in:	Chinese Medicine
Main Authors:	Guosheng Wu, Liang Ying, Qian Zhang, He Xiong, Jie Wang, Sitao Chen, Chen Yang, Yiyuan Jin, Zengwei Lai, Ninghan Feng, Yunjun Ge
Format:	Article
Language:	English
Published:	BMC 2024-12-01
Subjects:	Icaritin derivative Anti-tumor Lipid droplet Mitochondrial function DGAT1
Online Access:	https://doi.org/10.1186/s13020-024-01050-5