Allopregnanolone Decreases Evoked Dopamine Release Differently in Rats by Sex and Estrous Stage

Mesolimbic dopamine transmission is dysregulated in multiple psychiatric disorders, including addiction. Previous studies found that the endogenous GABAergic steroid (3α,5α)-3-hydroxy-5-pregnan-20-one (allopregnanolone) modulates dopamine levels in the nucleus accumbens and prefrontal cortex. As all...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Ana Paula S. Dornellas, Giovana C. Macedo, Minna H. McFarland, Alexander Gómez-A, Todd K. O’Buckley, Claudio Da Cunha, A. Leslie Morrow, Donita L. Robinson
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-01-01
Subjects:	neurosteroid allopregnanolone progesterone voltammetry dopamine nucleus accumbens
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2020.608887/full