Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia

Tetracyclines inhibit matrix metalloproteinases (MMPs) and reduce infarction volume following cerebral ischemia. In this thesis an involvement of urokinase could be proven. Cerebral ischemia in rats was induced for 3 h followed by 24 h reperfusion (suture model). Each 6 animals received orally eithe...

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Dorothe Burggraf, Andreas Trinkl, Martin Dichgans, Gerhard F. Hamann
Format:	Article
Language:	English
Published:	Elsevier 2007-03-01
Subjects:	Cerebral ischemia Doxycycline MMPs Plasminogen activator Rat TIMP
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996106002853