Interleukin-19 Gene-Deficient Mice Promote Liver Fibrosis via Enhanced TGF-β Signaling, and the Interleukin-19-CCL2 Axis Is Important in the Direction of Liver Fibrosis

IL-19 is a cytokine discovered by homologous searching with IL-10 and is produced by non-immune cells, such as keratinocytes, in addition to immune cells, such as macrophages. Liver fibrosis results from the inflammation and activation of hepatic stellate cells via chronic liver injury. However, the...

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Bibliographic Details
Published in:Biomedicines
Main Authors: Naoshige Ono, Takashi Fujita, Mariko Miki, Kazuhiro Nishiyama, Takeshi Izawa, Tomoko Aoyama, Mitsuru Kuwamura, Hideki Fujii, Yasu-Taka Azuma
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Subjects:
IL-19
liver
fibrosis
hepatic stellate cells
CCL2
Online Access:https://www.mdpi.com/2227-9059/11/7/2064

Internet

https://www.mdpi.com/2227-9059/11/7/2064

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