Distinct reduction in relative microglial glucose uptake compared to astrocytes and neurons upon isolation from the brain environment

IntroductionMicroglial energy metabolism has gained attention for the treatment of neurodegenerative diseases. In vitro methods provide important insights; however, it remains unclear whether the metabolism of highly motile microglia is preserved outside their regular environment. Therefore, we dire...

Full description

Bibliographic Details

Published in:	Frontiers in Cellular Neuroscience
Main Authors:	Sebastian T. Kunte, Johannes Gnörich, Philipp Beumers, Laura M. Bartos, Stephan Wagner, Karin Wind-Mark, Adrien Holzgreve, Dennis Pötter, Rudolf A. Werner, Sibylle Ziegler, Nathalie L. Albert, Alessio Colombo, Sabina Tahirovic, Matthias Brendel
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	microglia glucose uptake in vivo in vitro scRadiotracing
Online Access:	https://www.frontiersin.org/articles/10.3389/fncel.2025.1572431/full