Discovery of Selective Inhibitor Leads by Targeting an Allosteric Site in Insulin-Regulated Aminopeptidase

Insulin-Regulated aminopeptidase (IRAP) is a zinc-dependent aminopeptidase with several important biological functions and is an emerging pharmaceutical target for cognitive enhancement and immune system regulation. Aiming to discover lead-like IRAP inhibitors with enhanced selectivity versus homolo...

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Bibliographic Details

Published in:	Pharmaceuticals
Main Authors:	Ioannis Temponeras, Lykourgos Chiniadis, Athanasios Papakyriakou, Efstratios Stratikos
Format:	Article
Language:	English
Published:	MDPI AG 2021-06-01
Subjects:	aminopeptidase peptides lead-like inhibitors docking molecular dynamics free-energy calculations
Online Access:	https://www.mdpi.com/1424-8247/14/6/584