Analyzing the ER stress response in ALS patient derived motor neurons identifies druggable neuroprotective targets

Amyotrophic lateral sclerosis (ALS) is a degenerative motor neuron (MN) disease with severely limited treatment options. Identification of effective treatments has been limited in part by the lack of predictive animal models for complex human disorders. Here, we utilized pharmacologic ER stressors t...

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Bibliographic Details

Published in:	Frontiers in Cellular Neuroscience
Main Authors:	Michelle E. Watts, Richard M. Giadone, Alban Ordureau, Kristina M. Holton, J. Wade Harper, Lee L. Rubin
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-01-01
Subjects:	ALS ER stress iPSCs motor neurons proteomics phosphoproteomics
Online Access:	https://www.frontiersin.org/articles/10.3389/fncel.2023.1327361/full