Computer modelling reveals new conformers of the ATP binding loop of Na+/K+-ATPase involved in the transphosphorylation process of the sodium pump

Hydrolysis of ATP by Na+/K+-ATPase, a P-Type ATPase, catalyzing active Na+ and K+ transport through cellular membranes leads transiently to a phosphorylation of its catalytical α-subunit. Surprisingly, three-dimensional molecular structure analysis of P-type ATPases reveals that binding of ATP to th...

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Bibliographic Details

Published in:	PeerJ
Main Authors:	Gracian Tejral, Bruno Sopko, Alois Necas, Wilhelm Schoner, Evzen Amler
Format:	Article
Language:	English
Published:	PeerJ Inc. 2017-03-01
Subjects:	M4M5 loop Open and closed conformations Hinge movement Na+/K+-ATPase phosphorylation
Online Access:	https://peerj.com/articles/3087.pdf