Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence

Little is known about the role of glycolysis in cellular senescence. Here, authors report that glycolysis-derived serine biosynthesis activates PKM2 to phosphorylate histone H3T11, prevent cell senescence, and promote healthy aging.

Bibliographic Details
Published in:Nature Communications
Main Authors: Yinsheng Wu, Lixu Tang, Han Huang, Qi Yu, Bicheng Hu, Gang Wang, Feng Ge, Tailang Yin, Shanshan Li, Xilan Yu
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Online Access:https://doi.org/10.1038/s41467-023-37094-8

Internet

https://doi.org/10.1038/s41467-023-37094-8

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