PD-1 knockout on cytotoxic primary murine CD8+ T cells improves their motility in retrovirus infected mice

Cytotoxic T lymphocyte (CTL) motility is an important feature of effective CTL responses and is impaired when CTLs become exhausted, e.g. during chronic retroviral infections. A prominent T cell exhaustion marker is programmed cell death protein 1 (PD-1) and antibodies against the interaction of PD-...

وصف كامل

التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Frontiers in Immunology
المؤلفون الرئيسيون:	Daniela Mittermüller, Lucas Otto, Annika Loredana Kilian, Ann-Kathrin Schnormeier, Elisabeth Littwitz-Salomon, Anja Hasenberg, Ulf Dittmer, Matthias Gunzer
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Frontiers Media S.A. 2024-04-01
الموضوعات:	cytotoxic T lymphocytes cell motility anti-viral response retrovirus CRISPR/Cas9 PD-1
الوصول للمادة أونلاين:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1338218/full