Reconstructing mutational lineages in breast cancer by multi-patient-targeted single-cell DNA sequencing

Summary: Single-cell DNA sequencing (scDNA-seq) methods are powerful tools for profiling mutations in cancer cells; however, most genomic regions sequenced in single cells are non-informative. To overcome this issue, we developed a multi-patient-targeted (MPT) scDNA-seq method. MPT involves first pe...

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書誌詳細

出版年:	Cell Genomics
主要な著者:	Jake Leighton, Min Hu, Emi Sei, Funda Meric-Bernstam, Nicholas E. Navin
フォーマット:	論文
言語:	英語
出版事項:	Elsevier 2023-01-01
主題:	single-cell genomics triple-negative breast cancer intratumor heterogeneity mutational evolution breast cancer
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2666979X22001689