Preliminary clinical study of p-iodo benzoyl moiety-modified PSMA inhibitors and prospective comparison with 68Ga-PSMA-11

Abstract Small-molecule inhibitors targeting prostate-specific membrane antigen (PSMA) have demonstrated promising results in the theranostics of prostate cancer (PCa). We designed and synthesized a novel small-molecule PSMA inhibitor, SC691. This study aimed to conduct a preliminary clinical prospe...

Full description

Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Jianpeng Cao, Zhanliang Sun, Zhijun Zhou, Yilin Huang, Dengsai Peng, Xue Jiang, Yue Chen
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-06-01
Subjects:	Prostate Cancer Prostate-Specific membrane antigen (PSMA) 68Ga-SC691 68Ga-PSMA-11 PET/CT
Online Access:	https://doi.org/10.1038/s41598-025-05344-y