Senolytic treatment diminishes microglia and decreases severity of experimental autoimmune encephalomyelitis

Abstract Background The role of senescence in disease contexts is complex, however there is considerable evidence that depletion of senescent cells improves outcomes in a variety of contexts particularly related to aging, cognition, and neurodegeneration. Much research has shown previously that infl...

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Bibliographic Details
Published in:	Journal of Neuroinflammation
Main Authors:	Sienna S. Drake, Aliyah Zaman, Christine Gianfelice, Elizabeth M.-L. Hua, Kali Heale, Elia Afanasiev, Wendy Klement, Jo Anne Stratton, Alexandre Prat, Stephanie Zandee, Alyson E. Fournier
Format:	Article
Language:	English
Published:	BMC 2024-11-01
Subjects:	Microglia Multiple sclerosis Senescence Neuroinflammation Experimental autoimmune encephalomyelitis Senolytics
Online Access:	https://doi.org/10.1186/s12974-024-03278-2

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