ADAM17 variant causes hair loss via ubiquitin ligase TRIM47–mediated degradation

Hypotrichosis is a genetic disorder characterized by a diffuse and progressive loss of scalp and/or body hair. Nonetheless, the causative genes for several affected individuals remain elusive, and the underlying mechanisms have yet to be fully elucidated. Here, we discovered a dominant variant in a...

Full description

Bibliographic Details

Published in:	JCI Insight
Main Authors:	Xiaoxiao Wang, Chaolan Pan, Luyao Zheng, Jianbo Wang, Quan Zou, Peiyi Sun, Kaili Zhou, Anqi Zhao, Qiaoyu Cao, Wei He, Yumeng Wang, Ruhong Cheng, Zhirong Yao, Si Zhang, Hui Zhang, Ming Li
Format:	Article
Language:	English
Published:	American Society for Clinical investigation 2024-07-01
Subjects:	Dermatology Genetics
Online Access:	https://doi.org/10.1172/jci.insight.177588