The Iron Maiden. Cytosolic Aconitase/IRP1 Conformational Transition in the Regulation of Ferritin Translation and Iron Hemostasis

Maintaining iron homeostasis is fundamental for almost all living beings, and its deregulation correlates with severe and debilitating pathologies. The process is made more complicated by the omnipresence of iron and by its role as a fundamental component of a number of crucial metallo proteins. The...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Cécilia Hognon, Emmanuelle Bignon, Guillaume Harle, Nadège Touche, Stéphanie Grandemange, Antonio Monari
Format:	Article
Language:	English
Published:	MDPI AG 2021-09-01
Subjects:	molecular dynamics free energy profiles iron homeostasis aconitase IRP messenger RNA
Online Access:	https://www.mdpi.com/2218-273X/11/9/1329