Metformin Collaborates with PINK1/Mfn2 Overexpression to Prevent Cardiac Injury by Improving Mitochondrial Function

Both mitochondrial quality control and energy metabolism are critical in maintaining the physiological function of cardiomyocytes. When damaged mitochondria fail to be repaired, cardiomyocytes initiate a process referred to as mitophagy to clear defective mitochondria, and studies have shown that PT...

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Bibliographic Details

Published in:	Biology
Main Authors:	Zhuang Ma, Zuheng Liu, Xudong Li, Hao Zhang, Dunzheng Han, Wenjun Xiong, Haobin Zhou, Xi Yang, Qingchun Zeng, Hao Ren, Dingli Xu
Format:	Article
Language:	English
Published:	MDPI AG 2023-04-01
Subjects:	mitochondria PINK1 Mfn2 PGC-1α metformin isoprenaline
Online Access:	https://www.mdpi.com/2079-7737/12/4/582