Validation of an LC-MS/MS method for urinary homovanillic and vanillylmandelic ACIDS and application to the diagnosis of neuroblastoma

Background: Urinary catecholamine metabolites are well-established biomarkers for neuroblastoma (NB). Homovanillic acid (HVA) and vanillylmandelic acid (VMA) are the most frequently measured metabolites within SIOPEN – Catecholamine Working Group laboratories. Here, we evaluated the performance of a...

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Bibliographic Details

Published in:	Journal of Mass Spectrometry and Advances in the Clinical Lab
Main Authors:	Lucilla Rossi, Yvette A.H. Matser, Sebastiano Barco, Alessia Cafaro, Federica Pigliasco, Margherita Biondi, Fabrizio Mancin, Maria van der Ham, Monique G.M. de Sain-van der Velden, Shifra Ash, Maja Beck Popovic, André B.P. van Kuilenburg, Massimo Conte, Alberto Garaventa, Godelieve A.M. Tytgat, Giuliana Cangemi
Format:	Article
Language:	English
Published:	Elsevier 2025-04-01
Subjects:	Neuroblastoma Urinary catecholamine Liquid Chromatography-tandem Mass Spectrometry Pediatrics Inter-laboratory harmonization Homovanillic acid
Online Access:	http://www.sciencedirect.com/science/article/pii/S2667145X25000148