Prophylactic NAC promoted hematopoietic reconstitution by improving endothelial cells after haploidentical HSCT: a phase 3, open-label randomized trial

Abstract Background Poor graft function (PGF) or prolonged isolated thrombocytopenia (PT), which are characterized by pancytopenia or thrombocytopenia, have become serious complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Our previous single-arm trial suggests that...

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Bibliographic Details

Published in:	BMC Medicine
Main Authors:	Yu Wang, Yuan Kong, Hong-Yan Zhao, Yuan-Yuan Zhang, Ya-Zhe Wang, Lan-Ping Xu, Xiao-Hui Zhang, Kai-Yan Liu, Xiao-Jun Huang
Format:	Article
Language:	English
Published:	BMC 2022-04-01
Subjects:	N-Acetyl-L-cysteine Poor hematopoietic reconstitution Allogeneic hematopoietic stem cell transplantation Endothelial cells Bone marrow microenvironment
Online Access:	https://doi.org/10.1186/s12916-022-02338-9