Carbazole and tetrahydro-carboline derivatives as dopamine D3 receptor antagonists with the multiple antipsychotic-like properties

Dopamine D3 receptor (D3R) is implicated in multiple psychotic symptoms. Increasing the D3R selectivity over dopamine D2 receptor (D2R) would facilitate the antipsychotic treatments. Herein, novel carbazole and tetrahydro-carboline derivatives were reported as D3R selective ligands. Through a struct...

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Bibliographic Details

Published in:	Acta Pharmaceutica Sinica B
Main Authors:	Zhongtang Li, Fan Fang, Yiyan Li, Xuehui Lv, Ruqiu Zheng, Peili Jiao, Yuxi Wang, Guiwang Zhu, Zefang Jin, Xiangqing Xu, Yinli Qiu, Guisen Zhang, Zhongjun Li, Zhenming Liu, Liangren Zhang
Format:	Article
Language:	English
Published:	Elsevier 2023-11-01
Subjects:	Dopamine D3 receptor Carbazole derivatives Tetrahydro-carboline Bitopic ligand Antipsychotic
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211383523002861