Donor-But Not Recipient-Derived Cells Produce Collagen-1 in Chronically Rejected Cardiac Allografts

Fibrosis is a prominent feature of chronic allograft rejection, caused by an excessive production of matrix proteins, including collagen-1. Several cell types produce collagen-1, including mesenchymal fibroblasts and cells of hematopoietic origin. Here, we sought to determine whether tissue-resident...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Saidou Balam, Simone Buchtler, Frederike Winter, Kathrin Schmidbauer, Sophia Neumayer, Yvonne Talke, Kerstin Renner, Edward K. Geissler, Matthias Mack
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-01-01
Subjects:	transplantation fibrocytes collagen-1 allograft fibrosis chronic rejection
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.816509/full