The FAM104 proteins VCF1/2 promote the nuclear localization of p97/VCP

The ATPase p97 (also known as VCP, Cdc48) has crucial functions in a variety of important cellular processes such as protein quality control, organellar homeostasis, and DNA damage repair, and its de-regulation is linked to neuromuscular diseases and cancer. p97 is tightly controlled by numerous reg...

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Bibliographic Details

Published in:	eLife
Main Authors:	Maria Körner, Susanne R Meyer, Gabriella Marincola, Maximilian J Kern, Clemens Grimm, Christina Schuelein-Voelk, Utz Fischer, Kay Hofmann, Alexander Buchberger
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2023-09-01
Subjects:	p97 VCP Cdc48 ubiquitin proteasome system nuclear import DNA damage repair FAM104A FLJ14775 FAM104B FLJ20434 CXorf44
Online Access:	https://elifesciences.org/articles/92409