Targeting NAD + biosynthesis suppresses TGF-β1/Smads/RAB26 axis and potentiates cisplatin cytotoxicity in non-small cell lung cancer brain metastasis

Abstract Nicotinamide adenine dinucleotide (NAD+) plays an important role in tumor progression, but its role in non-small cell lung cancer with brain metastasis (NSCLC BM) remains unclear. Herein, we investigated NAD+ biosynthesis targeting as a new therapeutic strategy for NSCLC BM. Therapeutic act...

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出版年:	Acta Neuropathologica Communications
主要な著者:	Liyun Zhou, Zhiying Li, Shengli Zhou, Bin Wang, Zhen Liang, Sen Hu, Hang Zhang, Lin Duan, Dongxu Zhao, Luyao Cheng, Hang Ren, Hiroaki Wakimoto, Ming Li
フォーマット:	論文
言語:	英語
出版事項:	BMC 2025-03-01
主題:	Non-small cell lung cancer brain metastasis Nicotinamide adenine dinucleotide Cisplatin
オンライン･アクセス:	https://doi.org/10.1186/s40478-025-01967-4