Contextual regulation of T follicular helper cell expansion and differentiation into T regulatory type 1 cells by multiple transcription factors

Summary: Differentiation of naive T cells into T helper (TH), including T follicular helper (TFH), cell subsets is regulated by subset-specific transcription factors (TFs). We examine the role of 20 TFs binding to motifs enriched in open chromatin regions of TFH cells in the TFH-to-T regulatory type...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	Josep Garnica, Jun Yamanouchi, Shari Thiessen, Joel Moro, Enric Canut, Mireia Palou, Debajyoti Mondal, Pau Serra, Pere Santamaria
Format:	Article
Language:	English
Published:	Elsevier 2025-10-01
Subjects:	T-helper cells T-follicular helper cells T-regulatory type-1 cells transcription factors transdifferentiation immunoregulation
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124725011520