Molecular Mechanisms Controlling Foxp3 Expression in Health and Autoimmunity: From Epigenetic to Post-translational Regulation

The discovery of the transcription factor Forkhead box-p3 (Foxp3) has shed fundamental insights into the understanding of the molecular determinants leading to generation and maintenance of T regulatory (Treg) cells, a cell population with a key immunoregulatory role. Work over the past few years ha...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Alessandra Colamatteo, Fortunata Carbone, Sara Bruzzaniti, Mario Galgani, Clorinda Fusco, Giorgia Teresa Maniscalco, Francesca Di Rella, Paola de Candia, Veronica De Rosa
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-02-01
Subjects:	Foxp3 Treg cells epigenetic regulation Foxp3 stability autoimmunity
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2019.03136/full