Targeting macrophage Syk enhances responses to immune checkpoint blockade and radiotherapy in high-risk neuroblastoma

BackgroundNeuroblastoma (NB) is considered an immunologically cold tumor and is usually less responsive to immune checkpoint blockade (ICB). Tumor-associated macrophages (TAMs) are highly infiltrated in NB tumors and promote immune escape and resistance to ICB. Hence therapeutic strategies targeting...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Deepak Rohila, In Hwan Park, Timothy V. Pham, Riley Jones, Elisabette Tapia, Kevin X. Liu, Pablo Tamayo, Alice Yu, Andrew B. Sharabi, Shweta Joshi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-06-01
Subjects:	macrophage neuroblastoma immune suppression Syk T cells
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1148317/full