Transferrin receptor-targeting property of pabinafusp alfa facilitates its uptake by various types of human brain-derived cells in vitro

Pabinafusp alfa, which is an anti-mucopolysaccharidosis II drug, consists of iduronate-2-sulfatase (IDS) genetically fused with an anti-transferrin receptor (TfR) antibody. While IDS is known to enter cells via mannose-6-phosphate receptor (M6PR)-mediated endocytosis, the anti-TfR antibody moiety of...

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Bibliographic Details

Published in:	Frontiers in Drug Delivery
Main Authors:	Tomoki Fukatsu, Hanae Morio, Tomomi Furihata, Hiroyuki Sonoda
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-07-01
Subjects:	mucopolysaccharidosis II pabinafusp alfa iduronate-2-sulfatase blood-brain barrier transferrin receptor cellular uptake
Online Access:	https://www.frontiersin.org/articles/10.3389/fddev.2023.1082672/full