Detecting continuous structural heterogeneity in single-molecule localization microscopy data

Abstract Fusion of multiple chemically identical complexes, so-called particles, in localization microscopy, can improve the signal-to-noise ratio and overcome under-labeling. To this end, structural homogeneity of the data must be assumed. Biological heterogeneity, however, could be present in the...

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Bibliographic Details
Published in:Scientific Reports
Main Authors: Sobhan Haghparast, Sjoerd Stallinga, Bernd Rieger
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Online Access:https://doi.org/10.1038/s41598-023-46488-z