Mitochondrial reactive oxygen is critical for IL-12/IL-18-induced IFN-γ production by CD4+ T cells and is regulated by Fas/FasL signaling

Abstract Mitochondrial activation and the production of mitochondrial reactive oxygen species (mROS) are crucial for CD4+ T cell responses and have a role in naïve cell signaling after TCR activation. However, little is known about mROS role in TCR-independent signaling and in recall responses. Here...

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Bibliographic Details

Published in:	Cell Death and Disease
Main Authors:	Gorjana Rackov, Parinaz Tavakoli Zaniani, Sara Colomo del Pino, Rahman Shokri, Jorge Monserrat, Melchor Alvarez-Mon, Carlos Martinez-A, Dimitrios Balomenos
Format:	Article
Language:	English
Published:	Nature Publishing Group 2022-06-01
Online Access:	https://doi.org/10.1038/s41419-022-04907-5