Minor Isozymes Tailor Yeast Metabolism to Carbon Availability

ABSTRACT Isozymes are enzymes that differ in sequence but catalyze the same chemical reactions. Despite their apparent redundancy, isozymes are often retained over evolutionary time, suggesting that they contribute to fitness. We developed an unsupervised computational method for identifying environ...

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發表在:	mSystems
Main Authors:	Patrick H. Bradley, Patrick A. Gibney, David Botstein, Olga G. Troyanskaya, Joshua D. Rabinowitz
格式:	Article
語言:	英语
出版:	American Society for Microbiology 2019-02-01
主題:	cerevisiae duplicates genomics isozymes metabolomics paralogs
在線閱讀:	https://journals.asm.org/doi/10.1128/msystems.00170-18