SIRT5 regulates granulosa cell proliferation and apoptosis in polycystic ovarian syndrome via desuccinylation of GLI1

Polycystic ovarian syndrome (PCOS) is a major cause of infertility. Succinylation is involved in disease processes; however, its role in PCOS remains unknown. This study aimed to analyze the effect of desuccinylase SIRT5 on granulosa cell phenotype and the molecular mechanism. The levels of succinyl...

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Bibliographic Details

Published in:	Gynecological Endocrinology
Main Authors:	Yiwen Zhang, Fangfang He, Ning Cai, Guanmei Chen, Yinyin Wang, Weiwei Bai, Peng Guo
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2025-12-01
Subjects:	SIRT5 succinylation GLI1 granulosa cells SHH pathway polycystic ovarian syndrome
Online Access:	https://www.tandfonline.com/doi/10.1080/09513590.2025.2515516