Drug development concerning metallo-β-lactamases in gram-negative bacteria

β-Lactams have been a clinical focus since their emergence and indeed act as a powerful tool to combat severe bacterial infections, but their effectiveness is threatened by drug resistance in bacteria, primarily by the production of serine- and metallo-β-lactamases. Although once of less clinical re...

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Bibliographic Details

Published in:	Frontiers in Microbiology
Main Authors:	Xiuyun Li, Jing Zhao, Bin Zhang, Xuexia Duan, Jin Jiao, Weiwei Wu, Yuxia Zhou, Hefeng Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-09-01
Subjects:	antibiotic resistance metallo-β-lactamases novel drug strategies Escherichia coli Klebsiella pneumoniae Pseudomonas aeruginosa
Online Access:	https://www.frontiersin.org/articles/10.3389/fmicb.2022.959107/full