High-dose vitamin C promotes mitochondrial biogenesis in HCT116 colorectal cancer cells by regulating the AMPK/PGC-1α signaling pathway

Abstract Background Mitochondrial dysfunction is closely associated with cancer development. Colorectal cancer (CRC) cells often exhibit altered energy metabolism, characterized by increased glycolysis and reduced oxidative phosphorylation. Enhancing mitochondrial biogenesis and function may represe...

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Bibliographic Details
Published in:Journal of Cancer Research and Clinical Oncology
Main Authors: RuiYang Hong, Su Min, Jia Huang, Mou Zou, DongYu Zhou, Yun Liang
Format: Article
Language:English
Published: Springer 2025-05-01
Subjects:
Vitamin C
Colorectal cancer
Mitochondrial biogenesis
AMPK
PGC-1α
Online Access:https://doi.org/10.1007/s00432-025-06211-z

Internet

https://doi.org/10.1007/s00432-025-06211-z

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