The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson’s disease

Abstract Unique strains of α-synuclein aggregates have been postulated to underlie the spectrum of clinical and pathological presentations seen across the synucleinopathies. Whereas multiple system atrophy (MSA) is associated with a predominance of oligodendroglial α-synuclein inclusions, α-synuclei...

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Bibliographic Details

Published in:	Acta Neuropathologica Communications
Main Authors:	Heather H. C. Lau, Ivan Martinez-Valbuena, Raphaella W. L. So, Surabhi Mehra, Nicholas R. G. Silver, Alison Mao, Erica Stuart, Cian Schmitt-Ulms, Bradley T. Hyman, Martin Ingelsson, Gabor G. Kovacs, Joel C. Watts
Format:	Article
Language:	English
Published:	BMC 2023-05-01
Subjects:	Parkinson’s disease Multiple system atrophy α-synuclein Protein aggregation Strain Propagation
Online Access:	https://doi.org/10.1186/s40478-023-01570-5